Abstract
Because ovarian follicular growth occurs in three dimensions, and because follicular maturation (increased E(2)) is a result of an increase in the three-dimensional follicular surface area where testosterone (E(2) precursor)-producing theca interna cells are located, the three-dimensional follicular volume and the three-dimensional follicular surface area describe the three-dimensional follicular growth and maturation, respectively, more accurately than does the two-dimensional follicular diameter alone. Therefore, we present a mathematical model that describes the relationship of the two-dimensional follicular diameter, the three-dimensional follicular volume, and the three-dimensional follicular surface area to the three-dimensional follicular growth and maturation.
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