Abstract

Although animal and human studies have showed that antral follicle count and anti-Müllerian hormone has been suggested as good predictors of ovarian reserve, more researches are needed to standardize these threshold values universally. Bone morphogenetic protein 15 (BMP15), growth differentiation factor 9 (GDF9) are oocyte-secreted growth factor required for ovarian follicle development and ovulation in mammals. C-Kit has been also known to play an important role in follicle growth as a close coordinator secreted by granulosa cells.

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