Abstract
such damage can cause deleterious effects in the offspring, such as birth defects or childhood cancers (Aiken and Sawyer. Adv Exp Med Biol. 2003;518: 85-98). Zini noted that pregnancy is possible despite some degree of DNA damage, but little work has been done to evaluate the potential influence of sperm DNA damage on the health of resultant offspring. This may be particularly relevant for ICSI because this technique removes the natural barriers to fertilization and infertile men have higher levels of sperm DNA damage compared with fertile men. In addition, there is increasing concern regarding the safety of ICSI, which has been associated with significant increases in chromosomal abnormalities. Several studies have noted that an association may exist between ICSI and Beckwith-Wiedemann and Angelman syndromes. These are rare disorders arising fromabnormalgenetic imprinting,which is the process that silences either the maternal or paternal copy of a gene early in development (Powell. Nature. 2003;422: 656-658). “What is the implication of a successful ISCI pregnancy if you have damaged sperm DNA?” said Zini. “We don’t know the answer.”
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