Abstract
There is a rising death rate from ovarian cancer in advanced western countries. By contrast, ovarian cancer is uncommon in less developed areas. Mesotheliomas in asbestosis resemble ovarian cancer in appearance. Intraperitoneal injection of one variety of asbestos produces epithelial changes in the ovaries of guinea pigs and rabbits which are similar to those seen in patients with early ovarian cancer. Six of twelve patients with early ovarian malignant changes show birefringent crystalline material in the ovaries. These observations are compatable with the thesis that asbestos is an etiologic factor in ovarian cancer.
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