Abstract
Biomechanics is a physical phenomenon which mainly related with deformation and movement of life forms. As a mechanical signal, it participates in the growth and development of many tissues and organs, including ovary. Mechanical signals not only participate in multiple processes in the ovary but also play a critical role in ovarian growth and normal physiological functions. Additionally, the involvement of mechanical signals has been found in ovarian cancer and other ovarian diseases, prompting us to focus on the roles of mechanical signals in the process of ovarian health to disease. This review mainly discusses the effects and signal transduction of biomechanics (including elastic force, shear force, compressive stress and tensile stress) in ovarian development as a regulatory signal, as well as in the pathological process of normal ovarian diseases and cancer. This review also aims to provide new research ideas for the further research and treatment of ovarian-related diseases.
Highlights
Specialty section: This article was submitted to Gynecological Oncology, a section of the journal Frontiers in Oncology
The involvement of mechanical signals has been found in ovarian cancer and other ovarian diseases, prompting us to focus on the roles of mechanical signals in the process of ovarian health to disease
We review the roles of biomechanics in normal ovarian development and ovarian diseases, aiming to provide new insights into understanding the mechanisms of ovarian biomechanics
Summary
Specialty section: This article was submitted to Gynecological Oncology, a section of the journal Frontiers in Oncology. Mechanical signals participate in multiple processes in the ovary and play a critical role in ovarian growth and normal physiological functions. This review mainly discusses the effects and signal transduction of biomechanics (including elastic force, shear force, compressive stress and tensile stress) in ovarian development as a regulatory signal, as well as in the pathological process of normal ovarian diseases and cancer. As one of the main reproductive organs of the female reproductive system, the growth and development of the ovary are extremely complex processes involving the participation of multiple regulatory mechanisms, regulatory factors and effect factors. Some studies have suggestion that mechanical factors are involved in normal ovarian development and the malignant process of ovarian cancer in mammals and play vital roles [1,2,3,4,5]. Location shifts and tissue remodeling occur during follicle formation, suggesting that extracellular matrix (ECM) plays an important role in follicle development and that the mechanics involved in the process of ovarian growth and development have gradually attracted increased attention [10, 11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
