Abstract
BACKGROUND CONTEXT: Recombinant bone morphogenetic proteins (rhBMPs) have been used successfully in clinical trials. However, large doses of rhBMPs were required to induce adequate bone repair. Collagen sponges (CS) have failed to allow a more sustained release of rhBMPs. Ongoing research aims to design carriers that allow a more controlled and sustained release of the protein. EMatrix is a injectable scaffold matrix that may enhance rhBMP activity and stimulate bone regeneration.
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