Outside-in & Inside-out Signaling in Integrins: The Key Players in Schwann Cell Biology

Abstract

Event Abstract Back to Event Outside-in & Inside-out Signaling in Integrins: The Key Players in Schwann Cell Biology Lina Aires1*, Laura Montani1 and Joao B. Relvas1 1 Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), Portugal Myelination is essential for the normal development of the nervous system and greatly increases the conduction velocity of the nervous impulse. Control of myelination derives, at least in part, from signals originated within the extracellular environment from which growth factors and proteins of the extracellular matrix (ECM) are essential components.There is a significant body of evidence showing that during peripheral nervous system (PNS) development Schwann cells (SCs) need to interpret different extracellular cues to regulate their migration, proliferation and the remarkable morphological changes associated with myelination of axons. Recruitment of cytoskeleton and signaling molecules to cell matrix contact sites, where they link the actin cytoskeleton to the ECM, mediates signal transduction between the extracellular and the intracellular compartments (outside-in signaling). Among the integrins, the β1-integrin subunit is part of many integrin heterodimers and in Schwann cells the genetic deletion of the β1-integrin subunit gene causes defects in SC- axon contact and impairs the capacity of SCs to extend cytoplasmic processes into embryonic axons bundles to establish one-to-one relationships with individual axons, a process referred to as radial sorting.Our work focus the role of β1-integrins together with its interacting partners of the IPP complex (integrin- linked-kinase, PINCH and Parvin) and different Rho GTPases in Schwann cells biology during the development of the peripheral nervous system.Insights into such mechanisms will hopefully help us to better understanding of myelination and may suggest therapeutic approaches to Peripheral Neuropathies. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Poster Presentation Topic: Neuronal Communication Citation: Aires L, Montani L and Relvas JB (2009). Outside-in & Inside-out Signaling in Integrins: The Key Players in Schwann Cell Biology. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.140 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 11 Aug 2009; Published Online: 11 Aug 2009. * Correspondence: Lina Aires, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), Porto, Portugal, lina.adriana@ibmc.up.pt Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lina Aires Laura Montani Joao B Relvas Google Lina Aires Laura Montani Joao B Relvas Google Scholar Lina Aires Laura Montani Joao B Relvas PubMed Lina Aires Laura Montani Joao B Relvas Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.