Abstract
Stable cell lines provide scalable and high yielding production systems enabling the development of efficient manufacturing bioprocesses, essential for the supply of viral vectors for gene and cell therapies. The establishment of lentiviral vector producer cell lines is however very challenging. In this review, the major bottlenecks and achievements in the development of lentiviral vector stable cell lines are discussed. This is reported by Mariana V. Ferreira, Elisa T. Cabral, Ana Sofia Coroadinha in the article 2000017.
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