Outer membrane protein biogenesis in pathogenic Neisseria

Abstract

Neisseria gonorrhoeae (Ngo), is an obligate human pathogen and the causative agent of the disease gonorrhea. If left untreated, gonorrhea can lead to serious health issues including ectopic pregnancy and infertility. In addition to unsuccessful vaccine development, Ngo has rapidly become resistant to almost all classes of antibiotics, which contribute to over 500,000 drug resistant cases in year in the U.S. Due to this widespread resistance, the current recommended treatment option has become limited to a single drug of last resort: ceftriaxone.