Outcomes of Septuagenarian and Octogenarian Females Hospitalized For Heart Failure with Preserved Ejection Fraction

Abstract

Introduction Heart Failure with Preserved Ejection Fraction (HFpEF) is generally considered a disease of the elderly. Hospitalizations for HFpEF in the United States are rising, especially among women. It is largely unknown if there are any differences in-hospital outcomes between two elderly age groups of women admitted for acute HFpEF. Aim -To evaluate inpatient differences in outcomes between septuagenarian and octogenarian females admitted for acute HFpEF. Methods The United States Nationwide Inpatient Sample database was queried for hospitalizations of females aged 70 years and above with a primary diagnosis of HFpEF in 2016. Primary outcomes of interest include mortality, length of stay (LOS), and charges. A 1:1 propensity score matching (PSM) was performed to match octogenarians with septuagenarians based on race, region, and selected disease conditions. Outcomes were compared among matched cohorts using multivariable regression models. Results A total of 19,309 HFpEF hospitalizations were identified: 10,895 female patients were octogenarians, and 8,414 were septuagenarians. After PSM, 7,213 patients were matched in each group. Compared to septuagenarians, octogenarians were associated with increased odds of inpatient mortality (OR, 1.25 [1.02-1.54], P=0.0327), and an average of $4,973 less total hospital charges ($3271-$6675, P Conclusion Octogenarian hospitalizations compared to septuagenarian hospitalizations in women for HFpEF was associated with greater risk of in-hospital deaths, lower hospital charges, and decreased utilization of mechanical ventilation.