Outcomes of Preterm Infants with a Periventricular Venous Infarction in the Neonatal Period

Abstract

AbstractWe compared the neurodevelopmental outcomes of infants with and without a periventricular venous hemorrhagic infarction (PVHI). The study was designed as a case–control study. The primary outcome measure was any score of < 85 in at least one of the cognition, language, or motor domains of the Bayley Scales of Infant and Toddler Development-3rd edition (Bayley-III) at 18 to 24 months corrected age. Of 41 infants identified, 20 index infants were matched with 40 controls for analyses. No differences in the primary outcome were noted between the two groups of infants, 52.9% with PVHI compared with 62.5% without PVHI (OR: 0.68, 95% CI: 0.21–2.13; p = 0.56). Infants with a PVHI were likely to have cerebral palsy, 85% compared with 7.5%, with the majority (70%) being ambulatory. Infants with a PVHI were developmentally similar to their preterm counterparts as it related to cognition and language.