Abstract
<p class=MsoNormalCxSpFirst style=text-align:justify;mso-pagination:widow-orphan no-line-numbers; mso-mirror-indents:yes> Abstract <p class=MsoNormalCxSpMiddle style=text-align:justify;mso-pagination:widow-orphan no-line-numbers; mso-mirror-indents:yes> <span style=font-size:10.0pt;color:black;mso-themecolor:text1;mso-ansi-language: EN-US>Objectives: <span style=font-size:10.0pt;color:black; mso-themecolor:text1;mso-ansi-language:EN-US>As the population ages, a rise in Pelvic Organ Prolapse (POP) repair is expected. The aim of this study was to evaluate the efficacy and safety of POP repair by the vaginal route using a mixed polypropylene and porcine skin mesh (Avaulta Plus®) in elderly patients. <p class=MsoNormalCxSpMiddle style=text-align:justify;mso-pagination:widow-orphan no-line-numbers; mso-mirror-indents:yes> <span style=font-size:10.0pt;color:black;mso-themecolor:text1;mso-ansi-language: EN-US>Methods: <span style=font-size:10.0pt;color:black; mso-themecolor:text1;mso-ansi-language:EN-US>Retrospective study conducted at Tenon University Hospital, Paris, France including all women who underwent POP repair using Avaulta Plus® mesh by the transobturator route for POP ≥stage II from September 2008 to December 2017. Pre- and postoperative POP classification, quality of life scores, and complications were evaluated. All parameters were compared between the groups (≥80-year-old vs <p class=MsoNormalCxSpMiddle style=text-align:justify;mso-pagination:widow-orphan no-line-numbers; mso-mirror-indents:yes> <span style=font-size:10.0pt;color:black;mso-themecolor:text1;mso-ansi-language: EN-US>Results: <span style=font-size:10.0pt;color:black; mso-themecolor:text1;mso-ansi-language:EN-US>Twenty-one women ≥80 years and 58 women <80 years were included. There was no difference in anatomical success rate for anterior wall prolapse (100% in <80-year-old group and 96.1% in ≥80-year-old group). No differences in postoperative complication rate (p=0.53) or mesh exposure (p=0.19) were noted. An improvement in prolapse-related quality of life (PFDI-20 score) was observed for both groups. At 3 years of follow-up, the recurrence rate was similar in both groups. <p class=MsoNormalCxSpMiddle style=text-align:justify;mso-pagination:widow-orphan no-line-numbers; mso-mirror-indents:yes> <span style=font-size:10.0pt;color:black;mso-themecolor:text1;mso-ansi-language: EN-US>Conclusions: <span style=font-size:10.0pt;color:black; mso-themecolor:text1;mso-ansi-language:EN-US>Prolapse repair using Avaulta Plus® mesh is effective in elderly patients with similar improvements in symptoms and quality of life as in younger patients. Complication rate, including mesh exposure, does not increase with age. <p class=MsoNormalCxSpMiddle style=text-align:justify;mso-pagination:widow-orphan no-line-numbers; mso-mirror-indents:yes> Keywords: <span style=font-size:10.0pt;color:black; mso-themecolor:text1;mso-ansi-language:EN-US> Avaulta Plus® Mesh; Cystocele repair; Elderly patients; Pelvic organ prolapse; Quality of life
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