Outcomes of Patients With Clinical T1 Grade 3 Urothelial Cell Bladder Carcinoma Treated With Radical Cystectomy

Abstract

We read with great interest the report by Gupta et al. on the outcomes of patients with T1G3 urothelial cancer treated with radical cystectomy. 1 Gupta A. Lotan Y. Bastian P.J. et al. Outcomes of patients with clinical T1 grade 3 urothelial cell bladder carcinoma treated with radical cystectomy. Urology. 2008; 71: 302-307 Abstract Full Text Full Text PDF PubMed Scopus (57) Google Scholar We were dismayed to find that the authors incorrectly quoted our recent paper on T1G3 bladder cancer. 2 Masood S. Sriprasad S. Palmer J.H. et al. T1G3 bladder cancer indications for early cystectomy. Int Urol Nephrol. 2004; 36: 41-44 Crossref PubMed Scopus (49) Google Scholar The authors state in the discussion that, “Masood et al., for example, studied 30 patients and found that patients with multiple tumors (with or without concomitant CIS) or a single tumor with concomitant CIS had better survival than patients with a single tumor without CIS.” The conclusion from our study is, in fact, the opposite: patients with single tumors without CIS had the best outcomes in our study. Our results showed clearly that the presence of CIS is a poor prognostic factor, as is tumor multiplicity. We concluded that early radical cystectomy should be offered to patients with single T1G3 and CIS, as well as to those with multiple tumors with or without CIS. The study by Gupta et al. reiterates our conclusion that the presence of CIS is an indication for early cystectomy. Reply by the AuthorsUrologyVol. 72Issue 4PreviewWe agree with Drs. Mufti and Masood. We had incorrectly quoted their paper1 to state that patients with multiple tumors or a single tumor with concomitant CIS have better outcomes. In fact, their results showed the opposite, that patients with a single tumor without CIS have better outcomes than patients with multiple tumors or with a single tumor with concomitant CIS.1 We regret the error. Full-Text PDF