Outcomes of inhaled nitric oxide in preterm neonates - a five-year experience in a tertiary neonatal centre

Abstract

To review the outcome of preterm neonates treated with iNO. The neonatal electronic database was reviewed between April 1, 2009 and March 31, 2014. In the five-year period, 142 babies were treated with iNO. Forty-two preterm neonates <34(+0) weeks were included in this review. During this period, the use of iNO in preterm neonates <26(+0) weeks rose from 1.4% to 4.8% and the mortality was significantly higher in this group (69%). There is an increasing trend in using iNO as a rescue treatment in preterm neonates. The outcomes were very poor in the preterm neonates <26(+0) weeks. A cautious approach is warranted in the absence of robust evidence to support the use of iNO, in preterm neonates <26(+0) weeks.