Abstract
Objective:Chronic lymphocytic leukemia (CLL) is a heterogeneous disease in terms of survival with and without treatment. Many chemo and immunotherapeutic agents are available to treat this indolent disease. Aim of this study was to determine the outcomes of patients with chronic lymphocytic leukemia treated with different available chemotherapeutic regimens.Methods:All patients with diagnosis of CLL from 2008 to 2013 were included. Data were collected from hospital information system. Objective response rate (ORR) in terms of complete or partial response (CR, PR), stable or progressive disease (SD, PD), overall survival (OS), and progression free survival (PFS) were calculated.Results:Fifty seven patients were included; 42 (74%) male and 15 (26%) were female. Patients with Binet stage A 10 (18%); B 20 (35%) and C were 27(47%). Median age was 50.9 years. Forty six (80%) were treated and 11(20%) remained on watch and wait. Treatment indications were B symptoms 14 (30%), symptomatic nodal disease 18(39%), thrombocytopenia 4(9%), anemia 7(15%) and doubling of lymphocyte count 3 (7%). Chemotherapy regimens used were FC in 38 (83%), FCR 5(11%), chlorambucil 2(4%) and CVP in 1(2%) patient. Twenty two (56%) patients had CR, 13(33%) PR, 3(7.6 %) SD, and 1(2.5%) had PD. ORR was 89%. Median PFS was 23.1 months and median 3 years OS was 55%.Conclusion:Majority of patients was in a relatively younger age group and presented with advanced stage disease requiring treatment. Small number of patients received rituximab due to cost. PFS and OS are comparable with published literature.
Highlights
Chronic lymphocytic leukemia (CLL) is a disease of elderly, with male predominance and a median age of more than 70 years
Two patients developed acute kidney injury (AKI), one patient died before any intervention and one patient lost to follow up
Three patients treated with chlorambucil (2) or CVP (1) were excluded
Summary
CLL is a disease of elderly, with male predominance and a median age of more than 70 years. Median age is 58 years in familial cases.[1] CLL is an incurable disease with a remitting and Correspondence: April 26, 2016 July 14, 2016 July 25, 2016 relapsing course and life-long observation and follow-up is recommended. Treatment should only be initiated in patients with active disease that includes B symptoms, cytopaenias, symptoms or complications from lymphadenopathy, splenomegaly or hepatomegaly, lymphocyte doubling time of
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