Abstract
The novel coronavirus disease 2019 (COVID-19) is a global pandemic affecting millions of people worldwide. Solid organ transplant (SOT) recipients are probably at higher risk of severe infection and associated complications from COVID-19. Data on clinical outcomes of COVID-19 infection in SOT recipients are limited. Using the TriNetX database, patients with laboratory-confirmed COVID-19 from January 20, 2020, to July 7, 2020, were included in the study. We compared clinical outcomes comprising hospitalization, need for critical care services, intubation, and mortality among SOT recipients and patients without SOT. Of 30,573 laboratory-confirmed COVID-19 patients, 288 had SOT. Patients with SOT were more likely to be hospitalized (37.2% vs. 12.2%; p < 0.0001), needed critical care services (6.9% vs. 2.3%; p < 0.0001), needed intubation (7.9% vs. 2.0%; p < 0.0001), and had a higher 30-day mortality (11.1% vs. 3.8%; p < 0.0001). Patients in the transplant group were older (55.4 vs. 47.6 years; p < 0.0001) and had a higher prevalence of medical co-morbidities. SOT recipients are at significant risk of adverse COVID-19 related outcomes, including hospitalization, need for critical care services, and 30-day mortality, likely due to multiple co-morbid conditions.
Highlights
The ongoing pandemic of the novel coronavirus disease 2019 (COVID-19) infection has implied a tremendous health hazard on the world population
Solid organ transplant (SOT) recipients are at significant risk of adverse COVID-19 related outcomes, including hospitalization, need for critical care services, and 30-day mortality, likely due to multiple comorbid conditions
Solid organ transplant (SOT) recipients presumably are at high risk for COVID-19 infection, especially elderly SOT recipients aged > 60 years [2,3]
Summary
The ongoing pandemic of the novel coronavirus disease 2019 (COVID-19) infection has implied a tremendous health hazard on the world population. COVID-19 infection caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has posed tremendous mortality and morbidity risk and impacted financial, social, and emotional aspects of human well-being [1]. Solid organ transplant (SOT) recipients presumably are at high risk for COVID-19 infection, especially elderly SOT recipients aged > 60 years [2,3]. Low threshold for testing COVID-19 infection in transplant population is probably beneficial as they manifest atypical symptoms, predominantly diarrhea [4]. In determining the course of disease, cellular immunity plays a notable role, placing SOT recipients at potential risk of severe complications from COVID-19 infections [8]
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