Outcomes of albino Mice Liver Infected with Contaminated Camel Milk

Abstract

Background: Camel milk is an excellent source of nutrients and has medicinal importance for human in many countries all over the world especially in nomadic societies of Arab countries. Staphylococcus aureus (S. aureus) is instinctively present in milk and dairy products, and associated with many outbreaks. Milk is a good substrate for S. aureus rise and toxin production. When transmitted to human body this pathogen may affect skin, brain, kidney, liver and several other vital organs. Therefore, the pathological effects of S. aureus have been the focus of several recent research works.Aim: The present investigation was designed to better characterize the histopathological outcomes of contaminated raw camel milk with S. aureus on the mice liver. Materials and methods: S. aureus were isolated from specimens of lactating she-camels (Camelus dromedarius), weighing 300-540 kg, in Libya and identified using microbiological and molecular techniques. Twenty healthy male Swiss albino mice, weighing 22-25 gm, were divided into two groups; Group I (control) and Group II (orally injected mice with a single dose of aqueous solutions of the isolated bacteria at a concentration of 5x108/0.1ml). Animals sacrificed after three days of oral feeding with milk containing high bacterial load and their livers were dissected out for macro- and microscopic inspection.Results: Our study reported that infection with contaminated milk causes outer liquid-filled liver abscesses. Furthermore, various histopathological changes could be detected. Conclusion: This study may highlight the potential risk of consuming raw she-camel milk, especially upon lack of strict hygienic and preventative measures to avoid the presence of S. aureus in milk.