Abstract
This study was aimed to depict potential effects of stable formulation (water in oil emulsion), containing 3% green tea (Camellia sinensis L) extract on skin sebum production in healthy human volunteers. For this purpose formulation was designed using 3% ethanolic green tea extract and Abil®EM90 was used as an emulsifier. Formulation was applied to the cheeks of healthy human volunteers (n=10) for a period of 8 weeks. Measurements for skin sebum production were considered using Sebumeter MPA 5. Results were compiled and any effect produced by the formulation was justified statistically. It was observable that statistically significant (p < 0.5%) results were found for skin sebum production after long term application of the formulation. 3% formulation of green tea extract was ideal in all aspects and can be experienced in skin disorders like acne to further investigate its effects in unhealthy volunteers.
Highlights
Skin is considered excellent model for non-invasive topical delivery
Aim of this study was to test this formulation in healthy human volunteers for its effects on skin sebum production as many of the active constituents in green tea are prompted to contain anti-sebum effects declared by a study that green tea decreases hormonal activity because tea galltes and α- linoleic acid are selective inhibitors of α-reductase ( )
Green tea is powerful antioxidant ( ). erefore keeping in mind all above points of view, a desired dermatological formulation was of esteemed value using green tea extract
Summary
Skin is considered excellent model for non-invasive topical delivery. Topical emulsions have widespread acceptability by the user and have been used as dermatological formulations since long time ( ). More than years ago in Chinese history, emperor Sin-Non described that a daily cup of tea could be handy to dissolve number of poisons in our body. It was strongly believed in ancient culture that tea can prevent and treat many diseases. Catechins (polyphenols) are main active constituents found in tea ( ). Epidemiological studies suggest that tea is effective against variety of cancers and well known chemo preventive agent. Several other epidemiological studies suggest green tea effective in oral diseases, bone disorders, neurodegenerative and cardiovascular disorders ( ). Green tea is powerful antioxidant ( ). erefore keeping in mind all above points of view, a desired dermatological formulation was of esteemed value using green tea extract
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