Abstract
BackgroundRheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in the UK. This real-world study aimed to describe the characteristics, treatment patterns and clinical outcomes of patients who received abatacept in UK clinical practice.MethodsThis was a multi-centre, retrospective, observational study of patients with RA treated with abatacept at four UK centres between 01 January 2013 and 31 December 2017. Data were collected from medical records of each patient from the index date (date of first bDMARD initiation) until the most recent visit, death or end of study (31 December 2017).ResultsIn total, 213 patients were included in the study. Patients received up to eight lines of therapy (LOTs). Treatment with abatacept, or any other bDMARD, was associated with reductions in DAS28-ESR and DAS28-CRP scores at 6 and 12 months. The distribution of EULAR responses (good/moderate/no response) tended to be more favourable for patients when receiving abatacept than when receiving other bDMARDs (22.8%/41.3%/35.9% versus 16.6%/41.4%/42.1% at 6 months, and 27.9%/36.1%/36.1% versus 21.2%/34.5%/44.2% at 12 months). Patients receiving abatacept at LOT1 (n = 68) spent significantly longer on treatment compared with patients receiving other bDMARDs (53.4 vs. 17.4 months; p< 0.01); a similar trend was observed for LOT2. Among patients who discontinued after 6 months, a greater proportion experienced infection requiring antibiotics when receiving other bDMARDs compared to those receiving abatacept.ConclusionsRA patients who received bDMARDs, including abatacept, experienced reduced disease activity. When receiving abatacept as first or second line of therapy, patients persisted with treatment significantly longer than those receiving other bDMARDs.
Highlights
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in the United Kingdom (UK)
Patients receiving abatacept at LOT1 (n = 68) spent significantly longer on treatment compared with patients receiving other Biologic diseasemodifying antirheumatic drug (bDMARD) (Fig. 2, Table 2)
For patients receiving abatacept at LOT1, 85.6, 70.9 and 70.9% of patients were still in receipt of abatacept at 12, 24 and 36 months, respectively, compared with 63.4, 39.3 and 31.7% of patients receiving other bDMARDs, respectively
Summary
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that causes chronic synovitis, resulting in progressive joint destruction and functional disability and affects approximately 400,000 people in the UK. This real-world study aimed to describe the characteristics, treatment patterns and clinical outcomes of patients who received abatacept in UK clinical practice. Rheumatoid arthritis (RA) is a systemic autoimmune disease driven by both pro-inflammatory cytokines and pathogenic autoantibodies that causes chronic synovitis, resulting in progressive joint destruction and functional disability [1,2,3,4,5]. Positivity for rheumatoid factor (RF) and/or anti-citrullinated protein-peptide antibodies (ACPA) is a useful diagnostic and prognostic marker for RA as they may affect treatment response, with some evidence that the presence of these autoantibodies is associated with poorer outcomes [13,14,15,16,17,18]
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