Outcomes in Men with Large Prostates (≥60 g) Treated with Definitive Proton Therapy for Prostate Cancer

Abstract

Men with large prostates are at high risk of genitourinary (GU) and gastrointestinal (GI) toxicities after definitive radiotherapy for prostate cancer. Therefore, they may undergo cytoreduction with androgen deprivation therapy (ADT) before treatment, which negatively impacts their quality of life. Proton therapy (PT) can reduce the radiation dose to the nontargeted rectum and bladder and may obviate the need for cytoreduction. This is a retrospective study of the toxicity profile of men with large prostates (≥ 60 g) following definitive PT for prostate cancer.