Abstract
BackgroundWe performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches.MethodsDemographics, treatments and outcomes of patients diagnosed with Stage 3- 4B squamous carcinoma of the oropharynx, between 2000 – 2007 were tabulated and analyzed.ResultsThe cohort consisted of 1046 patients. The 5- year actuarial overall survival, recurrence-free survival and local-regional control rates for the entire cohort were 78%, 77% and 87% respectively. More advanced disease, increasing T-stage and smoking were associated with higher rates of local-regional recurrence and poorer survival.ConclusionsPatients with locally advanced oropharyngeal cancer have a relatively high survival rate. Patients’ demographics and primary tumor volume were very influential on these favorable outcomes. In particular, patients with small primary tumors did very well even when treatment was not intensified with the addition of chemotherapy.
Highlights
During the latter part of the 20th century, several changes occurred in the management and epidemiology of head and neck cancer
Intensity-modulated radiation therapy (IMRT) is a system of radiation treatment planning and delivery that allows for more optimal radiation dose distributions
Anderson Cancer Center (MDACC) was searched to identify patients irradiated for oropharyngeal carcinoma between the years 2000–2007
Summary
During the latter part of the 20th century, several changes occurred in the management and epidemiology of head and neck cancer. Incorporation of chemotherapy to improve disease control and allow for organ preservation was studied extensively during 1980 – 2000 [4]. Concomitant chemotherapy and radiation has become established as a standard of non-surgical care for patients with locally advanced disease. Sequential induction chemotherapy followed by definitive radiotherapy, with or without concomitant chemotherapy, remains under study; there has Intensity-modulated radiation therapy (IMRT) was developed during the last decade of the 20th century. Favorable early reports published in the first few years of the past decade [6,7,8] led to the incorporation of IMRT into many cooperative group trials, and there has been a striking increase between 2000–2010 in the use of IMRT as a routine therapy for head and neck cancer [9]. We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches
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