Outcomes and Durability of Endovascular Aneurysm Repair in Octogenarians

Abstract

Endovascular aneurysm repair (EVAR) accounts for the majority of all abdominal aortic aneurysm (AAA) repairs in the United States. EVAR utilization in the aging population is increasing due to the minimally invasive nature of the procedure, the low associated perioperative morbidity, and early survival benefit over open repair. The objective of this study is to compare the outcomes of octogenarians after elective EVAR to theiryounger counterparts, a question that can be answered by a long-term, institutional data set. This was a retrospective series of 255 patients, who underwent elective EVAR within our institution from 2008 to 2015. A comparative analysis of patients aged 80years and older and less than 80years was performed. Outcomes measured included perioperative death and myocardial infarction (MI), length of stay, and readmission within 30days. Aneurysm reintervention, long-term surveillance imaging, and aneurysm-related deaths were also evaluated. In addition, subset analyses of octogenarians were compared for survival at 24months. Overall, 255 patients were included in our analysis. Fifty-nine patients were octogenarians, and 196 patients were nonoctogenarians. The mean age difference between the two groups was significant (84.5years [SD, ±3.44] vs. 69.6years [SD, ±6.13] in the ≥80 and <80 groups, respectively; P<0.0001). There was no significant difference in the mean aneurysm size (6.03cm [SD, ±1.12] vs. 5.535cm [SD, ±0.9]; P<0.06) between the ≥80 and<80 groups. Octogenarians had higher rates of perioperative MI (5% vs. 1%, P<0.04), thirty-day mortality (7% vs. 0%, P<0.003), a higher number of perioperative complications (0.64 incidence per patient [SD, ±1.11] vs. 0.31 [SD, ±0.69], P<0.005), and a longer mean hospital stay (5.34 [SD, ±5.75] days vs. 3.16 [SD, ±3.23] days, P<0.0003), and they were also less likely to be discharged home after surgery (75% vs. 91%, P<0.002). In the evaluated long-term outcomes, the two groups were similar with regard to aneurysm reintervention (10% vs. 9%, P<0.06) and the stability of aneurysm sac size on imaging at last follow-up (71% vs. 80%, P<0.27). The overall aortic related cause of death was different between the groups (8% vs. 1%, P<0.003); however, the long-term aortic related mortality was not different between the two groups (2% vs. 1%, P<0.4). Finally, a subset analysis of the octogenarian group was performed comparing patients based on survival status at 24months. Higher preoperative creatinine (1.73mg/dL [SD, ±1.54] vs. 1.15mg/dL [SD, ±0.46]) and lower preoperative hematocrit (33.9% [SD, ±3.43] vs. 37.2% [SD, ±4.9]) along with number of perioperative complications (1.2 incidence per patient [SD, ±1.74] vs. 0.45 [SD, ±0.73]) were associated with death at 24months after the index operation. Elective endovascular repair of AAA in octogenarians carries a higher risk of perioperative mortality but acceptable long-term outcomes. Appropriateness of elective EVAR in octogenarians should be answered based on this potential short-lived survival benefit, taking into account that advanced age should not be the sole basis of exclusion for otherwise suitable candidates for elective EVAR.