Outcome research in meningococcal septic shock

Abstract

We thank Dr Paize and Dr Playfor for their comments [1] regarding our earlier article in Critical Care [2]. In their commentary Dr Paize and Dr Playfor stated that the reasons for a marked reduction in the mortality of children with meningococcal disease in the paediatric intensive care unit are multifactorial: increased centralization of the paediatric intensive care unit, improvement in awareness, clinical guidelines for children with sepsis, and incorporation of meningococcal serogroup C vaccine. Dr Paize and Dr Playfor also regretted in their commentary that we did not examine morbidity in our large cohort [1]. We completely agree with Dr Paize and Dr Playfor that both short-term and long-term outcomes in survivors of meningo-coccal sepsis are clinically highly relevant. Only a few, unsystematic studies have been conducted in this field. These studies used small, heterogeneous patient samples and unstandardized assessment procedures and were focused mainly on short-term outcome. Our relatively large, homogeneous cohort therefore offered the possibility to investigate this neglected area of outcome, both from a medical and psychosocial point of view, with standardized procedures. Parts of our outcome study have been published already or are in press [3-6]. In a prospective cohort study we performed a short-term follow-up of all consecutive children with septic shock and purpura requiring intensive care treatment between 2001 and 2005, and their parents [4]. Up to 2 years after paediatric intensive care unit discharge, chronic complaints were reported in nearly one-half of the children. Significantly lower scores were found on health-related quality-of-life scales concerning mainly physical functioning and health perception in comparison with normative data. Quite a few mothers suffered from anxiety or depression requiring professional help. The second part of our study concerned a cross-sectional long-term outcome study of all 179 survivors of septic shock and purpura requiring intensive care treatment between 1988 and 2001, and their parents [3,5,6]. Regarding long-term health-related quality of life, we found significantly lower scores in patients – mainly on physical domains (physical functioning, general health perception) – compared with Dutch normative data [3]. Adolescents (aged 12–17 years) who survived meningococcal septic shock in childhood, especially those with skin scarring due to purpura, reported lower self-esteem compared with reference adolescents [5]. Overall, we found favourable long-term behavioural, emotional and post-traumatic stress outcomes in patients [6]. Articles regarding skin scarring, orthopaedic and neurological sequelae, as well as psychosocial adjustment of parents, are under review. In conclusion, we would like to reassure Dr Paize and Dr Playfor that we did study short-term and long-term morbidity in survivors of septic shock and purpura.