Abstract
To compare the efficacy of a modified PRN treatment regimen ("treat and monitor") of aflibercept and ranibizumab in macular edema secondary to non-ischemic branch retinal vein occlusion. Seventy eyes of 70 patients with treatment naïve branch retinal vein occlusion were enrolled. All patients underwent a comprehensive ophthalmic examination, spectral-domain optical coherence tomography, and fluorescein angiography. Patients were randomized 1:1 to receive intravitreal aflibercept (34 eyes) and ranibizumab (36 eyes) with a "treat and monitor" treatment regimen with monthly follow-up for 12months. Primary outcome measures included mean change in best corrected visual acuity (BCVA) and central foveal thickness (CFT) at month 12 compared to baseline. At 12months follow-up, the mean BCVA improved from 0.58±0.13 to 0.20±0.15 logMAR (P=0.0003) in the aflibercept group (mean injections 2.6±1.51) and from 0.52±0.11 to 0.21±0.1 logMAR (P=0.0002) in the ranibizumab group (mean injections 2.8±1.78). No statistical difference between the two groups in terms of the visual acuity gains in eyes with macular edema secondary to non-ischemic BRVO treated with either aflibercept or ranibizumab was observed. Mean CFT reduced from 498±46 to 204±23µm (P<0.0001) in the aflibercept group and from 488±31 to 212±29µm (P<0.0001) in the ranibizumab group. "Treat and monitor" regimen is a real-life effective strategy in improving visual acuity after macular edema from branch vein occlusion and in reducing the number of injections.
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