Outcome of Toxoplasma gondii Mismatch in Lung Transplant Recipients After Prophylaxis With Pyrimethamine and Leukovori

Abstract

PURPOSE: Toxoplasma gondii is an important cause of morbidity and mortality in solid organ transplant recipients. Patients with a serologic mismatch (donor positive/ recipient negative) are at higher risk for toxoplasmosis, and prophylaxis has been effective for certain solid organ transplant recipients. The incidence of toxoplasma mismatch and the efficacy of prophylaxis have not been studied in lung transplant recipients. Our aim is to determine the incidence of T. gondii serologic mismatch in the lung transplant population and report the incidence of toxoplasmosis in patients receiving pyrimethamine and leukovorin prophylaxis.