Outcome of Tibial Fractures Cleaned and Irrigated with Tetrachlorodecaoxygen Solution and Primary Plate Fixation

D Ismono,H Herman

doi:10.5704/moj.0905.012

Abstract

In this study we seek to evaluate the value of tetrachlorodecaoxygen as an intra and postoperative adjuvant in the surgical management of primarily closed tibial fractures fixed with plate and screws. We reasoned that its prophagocytic and antiinflammation properties should decrease acute inflammation and associated complications. Of 41 cases of tibial fractures included in the study, seven were grade III open fractures. No adverse effects were observed from the use of tetrachlorodecaoxygen. There was no occurrence of acute compartment syndromes or chronic deep tissue infections. All subjects were able to bear weight within 16 to 24 weeks. We concluded that the use of tetrachlorodecaoxygen is of benefit when used as an adjuvant in the primary fixation and wound closure of tibial fractures.

Highlights

In this study we seek to evaluate the value of tetrachlorodecaoxygen as an intra and postoperative adjuvant in the surgical management of primarily closed tibial fractures fixed with plate and screws
It is an agent that is currently used to attenuate inflammation in transplantation patients, and patients with chronic inflammation due to immunosuppression. This agent is capable of promoting local immunity while at the same time restricting inflammation by augmenting phagocytic activity of macrophages and suppressing macrophage ability to recruit other inflammatory cells by interfering with its antigen presenting activity . 9,10 A prototype of tetrachlorodecaoxygen, WF10, has been shown to be safe and has had promising results when used as an adjuvant in a systemic therapy against transplant rejection and chronic infection associated with immunocompromised patients . 11-14 In the present study, we evaluated the use of tetrachlorodecaoxygen, for cleaning and irrigating tibial fractures managed with primary plate fixation, including open fracture cases where wounds are primarily closed
Gustillo proposed a categorization based on the degree of injury to the soft tissue; open fractures with wound sizing less than 1 cm are classified as grade I, open fractures with wound sizing less than 10 cm are classified as grade II, open fractures with wound sizing more than 10 cm are classified as grade III 3

Summary

Introduction

In this study we seek to evaluate the value of tetrachlorodecaoxygen as an intra and postoperative adjuvant in the surgical management of primarily closed tibial fractures fixed with plate and screws. We concluded that the use of tetrachlorodecaoxygen is of benefit when used as an adjuvant in the primary fixation and wound closure of tibial fractures. 11-14 In the present study, we evaluated the use of tetrachlorodecaoxygen, for cleaning and irrigating tibial fractures managed with primary plate fixation, including open fracture cases where wounds are primarily closed. One management option for tibial fractures is primary plate and screw fixation, but it has been associated with acute and/or chronic inflammation attributed to the extensive softtissue damage resulting from the surgical procedure, in addition to the initial damage caused by the trauma .5-8. One management option for tibial fractures is primary plate and screw fixation, but it has been associated with acute and/or chronic inflammation attributed to the extensive softtissue damage resulting from the surgical procedure, in addition to the initial damage caused by the trauma .5-8 Tetrachlorodecaoxygen may help to decrease inflammation and associated complications stemming from plate and screw

Methods

Results

Conclusion