Abstract
Background: Central nervous malformations are associated with major morbidity and mortality in infants and children. Knowledge of the data about their outcome and neurodisability will help in perinatal counseling and aid in parental decision-making. Objective: To study the fetal and neonatal characteristics of prenatally diagnosed central nervous system (CNS) malformations and the neurodevelopmental outcome of the survivors over 5years. Methods: Maternal and neonatal records of prenatally diagnosed CNS malformations were retrospectively reviewed over five years (January 2005 till December 2009). The relevant fetal and neonatal data were collected from the database maintained by the birth defect registry. The long-term neurodevelopment data was obtained from case records. Results: There were 116 cases of fetal structural CNS malformations. Termination of pregnancy or fetal deaths occurred in 80/116 (69%) of cases, of which 68% had Neural tube defects (NTD). There were 36 live births, of which six infants died of anencephaly and were not included in the study. Among 30 live births 17% of infants needed ventilator support and 17% had neurosurgical intervention. On follow up 37% of the cohort had neurodevelopmental delay, 10% died, 30% had normal neurodevelopmental outcome and 23% defaulted on follow-up. Conclusions: In two-thirds of the fetuses of prenatally diagnosed CNS malformations, termination of pregnancy or fetal death occurred. Nearly half of the survivors who were followed up had a composite outcome of death or global neurodevelopmental delay and need for support services.
Highlights
Fetal anomalies are recognized as one of the leading causes of morbidity and mortality among infants and children [1]
This study aims to examine the prevalence of major congenital central nervous system (CNS) malformations and their outcome over five years
The term global developmental delay (GDD) is used to describe developmental disability in children with significant delay in at least two of the major domains of development: gross and fine motor, speech and language, cognition, social and personal development and activities of daily living. During this five-year period, we identified 116 structural CNS malformations (Table 1)
Summary
Fetal anomalies are recognized as one of the leading causes of morbidity and mortality among infants and children [1]. Accurate prenatal diagnosis of fetal anomalies allows parents to assess the immediate. Central nervous malformations are associated with major morbidity and mortality in infants and children. Objective: To study the fetal and neonatal characteristics of prenatally diagnosed central nervous system (CNS) malformations and the neurodevelopmental outcome of the survivors over 5years. Methods: Maternal and neonatal records of prenatally diagnosed CNS malformations were retrospectively reviewed over five years (January 2005 till December 2009). Termination of pregnancy or fetal deaths occurred in 80/116 (69%) of cases, of which 68% had Neural tube defects (NTD). Conclusions: In two-thirds of the fetuses of prenatally diagnosed CNS malformations, termination of pregnancy or fetal death occurred. Half of the survivors who were followed up had a composite outcome of death or global neurodevelopmental delay and need for support services
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Pediatric Review: International Journal of Pediatric Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.