Abstract
4197 Background: Chemoradiation therapy including gemcitabine has a significant impact on the survival and quality of life in patients with locally advanced pancreatic cancer. Twice-weekly gemcitabine administration has reported to result in an enhanced radiation sensitizing effect. Our aim was to examine the feasibility and effectiveness of electron-beam intraoperative radiation therapy (IORT) and concurrent external beam radiation therapy (EBRT) with twice-weekly gemcitabine administration as a radiosensitizer. Methods: In twenty patients with registration, five patients with stage III disease (UICC) and 12 patients with stage IV disease have completed the treatment from October 2001 to December 2004. Gemcitabine treatment (600 mg/m2) by 30-minute intravenous infusion was performed 24 hours prior to IORT. IOR was administered at a dose of 24–28 Gy, and directed to the pancreatic tumor and regional lymph nodes. Eight to ten days after IORT, patients were treated with 27 Gy EBRT (1.8 Gy/fraction x 15 frac...
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