Outcome of patients with primary sclerosing cholangitis and ulcerative colitis undergoing colectomy

Abstract

Background and Aim: Patients with ulcerative colitis (UC) are at risk of developing primary sclerosing cholangitis (PSC). As a form of continence preservation, ileal pouch-anal anastomosis or ileorectal anastomosis are used for patients undergoing colectomy. The present study aimed to determine the patient outcomes following colectomy for primary sclerosing cholangitis and ulcerative colitis. Patients and Methods: 64 patients with PSC and UC undergoing colectomy were enrolled and investigated in the Department of Gastroenterology, Lady Reading Hospital, Peshawar from January 2018 to June 2020. Study protocol was approved by the institutional research and ethical committee. Patient’s data regarding clinical information, preoperative liver tests, colectomy date, pathological findings, and follow-up liver tests were reviewed from medical records. The colectomy-leading indications such as colonic dysplasia, bowel perforation, and colonic inflammation etc. were recorded. Several preoperative tests were conducted, including total bilirubin, albumin levels, direct bilirubin and ALP. SPSS version 26 was used for data analysis. Results: The overall mean age was 40.42±3.6 years. Of the total 64 patients, there were 42 (65.6%) male and 22 (34.4%) females. Colectomy was most commonly indicated by severe intestinal inflammation (52%), bowel perforations (4%), and dysplastic colons (38%). The incidence of postoperative complications were 43.8% (n=28).