OUTCOME OF PATIENTS WITH COMORBIDITY IN TB

Abstract

SESSION TITLE: Late-breaking Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: 1) To study the burden of comorbidities associated with Tuberculosis patients presented to a tertiary care setting. 2) To assess the outcome of Tuberculosis treatment with anti tubercular drugs in patients with comorbidities. METHODS: This was a nonconcurrent cohort study done in Amrita Institute of Medical Science & Research Centre, Kerala, India. Patient’s data collected using medical record number from hospital data base. Patient’s demographic features, type of TB , bacteriological status and comorbidities captured by using a performa and was entered in Microsoft excel version 2007.All patients diagnosed as tuberculosis and those treatment started from the institution during first and second quarter of the year of 2016 were included in the study. Patients were classified as Pulmonary and extrapulmonary ,microbiologically positive and clinically diagnosed as per national control program guideline. Comorbidity of all Tuberculosis patients listed. Treatment outcomes were categorized as succesful outcome and unsuccessful outcome Chi-square was done to see the association of comorbidities with outcome. RESULTS: Of the 150 patients,88 were males and 62 were females. 70 patients (46.67%) were pulmonary tuberculosis and 80 patients (53.33%) were extra pulmonary tuberculosis.90 (60%) patients were bacteriologically positive and 60(40%) patients were clinically diagnosed as Tuberculosis.In our study 42.6% (64/150) had at least one comorbidity . Most common comorbidity observed was Diabetes mellitus (DM) 28% ( 42/150) followed by chronic respiratory diseases 19.33%(29/150). Among Pulmonary TB and Extrapulmonary TB ,DM was most common comorbidity (38% and 18.75%). Hypertension (15.33%) and Dyslipidemia (8.67%) were also seen in TB patients. Overall success rate of treatment is 86.67%(130/150).Overall unsuccessful outcome was 12.6%(19/150)%.Chronic Liver disease is the most common major comorbidity with successful outcome (100%).Diabetes was the most common comorbidity with unsuccessful outcome.(16.6%) followed by Chronic Respiratory disease(13.8%). In 42.8 % (18/42)of patients with DM ,ATT were extended beyond 6 months for a successful outcome and completed treatment. 37/150 patients(24.67%) needed modification of drugs from conventional regimen due to comorbidity .46 patients(30.67%) patients needed extended treatment more than 6 months .Most common comorbidity in which regimen extended were Connective tissue diseases 4/5(80%) There was significant association with comorbidity and outcome of treatment (P=.000019). CONCLUSIONS: In Our study Diabetes and Chronic Respiratory diseases were found to be the common comorbidities associated with Tuberculosis and there was a significant association in treatment outcome CLINICAL IMPLICATIONS: . Strategies for early identification and control of comorbid conditions will ensure optimal management and outcome in tuberculosis DISCLOSURES: No relevant relationships by Richie George, source=Web Response No relevant relationships by Nithya Haridas, source=Web Response No relevant relationships by vishnu Krishnan, source=Web Response No relevant relationships by Akhilesh Kunoor, source=Web Response No relevant relationships by Asmita Mehta, source=Web Response No relevant relationships by Tisa Paul, source=Web Response No relevant relationships by Arun Raj, source=Web Response