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Abstract
Objective:To evaluate the effects of a gonadotropin releasing hormone agonist (GnRHa) injection prior to embryo transfer on implantation and pregnancy rate.Materials and Methods:We performed a retrospective analysis of patients undergoing in vitro fertilization (IVF) therapy with and without GnRHa preinstallation into the uterine cavity just before embryo transfer between January 2012 and March 2013 in a single IVF center of a university hospital. Patients were evaluated based upon implantation, pregnancy, live birth, and miscarriage rates.Results:GnRHa was injected into the uterine cavity of 108 patients prior to embryo transfer which were regarded as study group. One thousand forty-seven patients who were not injected GnRHa were regarded as the control group. Pregnancy rates were 44.4% and 41.7% in the GnRHa and control groups, respectively. Live birth rates were 27.8% and 26.1%, miscarriage rates were 15.7% and 15.7%, and implantation rates were 31% and 30%, respectively and there were no difference between groups statistically (p>0.05).Conclusion:No statistically significant differences in implantation, pregnancy, live birth, or miscarriage rates were observed in patients treated with GnRHa prior to embryo transfer, relative to the controls. Therefore, GnRHa injection into the uterine cavity prior to embryo transfer is not recommended as a means of increasing implantation or pregnancy rates in IVF. However, prospective randomized controlled studies are needed to clarify the effect of GnRHa instillation in the uterine cavity for embryo implantation in IVF.
Highlights
The success of in vitro fertilization (IVF) as a means of achieving clinical pregnancy is primarily dependent on the presence of high quality embryos and a suitable endometrium for implantation
No statistically significant differences in implantation, pregnancy, live birth, or miscarriage rates were observed in patients treated with gonadotropin releasing hormone agonist (GnRHa) prior to embryo transfer, relative to the controls
We evaluated the effects of GnRHa injection prior to embryo transfer (ET) on implantation and pregnancy rates in our IVF programme executed between January 2012 and March 2013
Summary
The success of in vitro fertilization (IVF) as a means of achieving clinical pregnancy is primarily dependent on the presence of high quality embryos and a suitable endometrium for implantation. Progesterone, estradiol, human chorionic gonadotropin (hCG), or gonadotropin releasing hormone agonists (GnRHa) have been evaluated in a variety of clinical studies as a means of luteal phase support to increase implantation and pregnancy rates in IVF[2,3,4,5]. We compared the effects of GnRHa injected directly into the uterine cavity prior to ET on implantation rate, pregnancy, and live birth rates
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