Outcome of early and late vitrectomy for retinal detachment associated with von Hippel–Lindau-related retinal capillary hemangioma

Abstract

Aim: The aim of this study was to report the outcome of early and late vitrectomy for retinal detachment-associated with von Hippel–Lindau (VHL)-related retinal capillary hemangioma (RCH). Materials and Methods: Records of patients diagnosed with VHL-related RCH, from 2016 to 2018, were retrospectively analyzed for patients' age, gender, family history, systemic disorders, previous treatment taken, clinical characteristics of RCH, associated complications, timing of surgery, and surgical outcome. The treatment of RCH depends on its location, size, and clinical expressions. Results: Twenty-one eyes of 15 patients with a median age of 40 years (range, 22–65 years) were seen. Nine patients had central nervous system hemangioblastomas, eight had associated renal complications (four – renal cell carcinoma and four – multiple renal cysts), four had pancreatic cysts, while one had testicular cyst and pheochromocytoma each. Four eyes presented with no perception of light. Eight eyes presented with retinal detachment (RD). Four eyes underwent a combination treatment, four underwent cryotherapy, five underwent laser, and two underwent transpupillary thermotherapy, while four underwent intravitreal bevacizumab. Of eight eyes with tractional RD (TRD), four presented with no perception of light (NPL) . The other four eyes underwent surgery. Of the eyes that underwent surgery, two underwent early vitrectomy for extramacular TRD, whereas the other two underwent surgery in late stage. The two eyes that underwent early vitrectomy gained best-corrected visual acuity (BCVA) of 20/20, and the retina was attached in single surgery. The other two eyes that underwent surgery at an advanced stage had to undergo multiple surgeries and gained BCVA