Abstract
Indications for prophylaxis and treatment of recurrent FSGS after renal transplantation (Tx) are controversial. We have reviewed our experience with 40 pediatric patients (37 cadaver grafts) grafted from 1970 – 1995 because of primary NS associated with FSGS. Mean age at 1st Tx was 10.9 yrs and mean follow-up 4.9 yrs. Five pts received a 2nd graft. 12 pts developped recurrent NS or severe proteinuria after the 1st Tx. Two of the three recipients of living-related grafts developed recurrent NS. Mean age at onset of NS was higher in pts with recurent NS than in the non-recurrent cases (6.6 vs 4.9 yrs) and duration from onset of NS to ESRD was shorter (3.3 vs 7.2 yrs). 5/12 pts with recurrent and 11/28 pts with non-recurrent disease lost their 1st graft. Mean 1st graft survival was similar in recurrent and in non-recurrent disease. Proteinuria disappeared in 1 pt following introduction of Cyclosporine A (3 mg/kg/d) after 7 yrs of severe NS; serum creatinine is 204 μM/I 18 yrs post Tx. In 2 other pts proteinuria decreased after plasma exchange supplemented by oral cyclophosphamide.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
