Abstract
Aim and objectives: Herbal drugs such as, Capparis Spinosa (CS) has been used to treat several diseases from heart and cardiovascular disorders to diabetes in traditional Iranian medicine. The present study was aimed to determine beneficiary effects of CS fruit extract on a number of tissues in healthy and type 1 diabetic rat. Materials and methods: In this experimental study, sixty male wistar rats were randomly divided into 6 groups (n=10) and subjected to gavage tube therapy for one months by following protocol: group I and IV: diabetic control and non-diabetic control rats which only received distilled water; groups II and III: non diabetic treatment rats which received 200 mg/kg and 800 mg/kg CS extract per day respectively; groups V and VI: diabetic treatment rats which received 200 mg/kg and 800 mg/kg CS extract per day respectively. Diabetes was induced by intra-peritoneal injection of 50 mg/kg of streptozotocin (STZ). After 4 weeks, their blood were collected and the serum levels of creatinine, bilirubin, urea, uric acid, AST, ALT and ALP were measured. The liver, kidney, pancreas and stomach tissues were immediately excised, and after slide preparation processes, the histological changes were studied. Results: Our results illustrated that the gastric tissue in the diabetic group showed a small degree of changes and was not affected significantly by administration of the CS fruit extract. Liver, pancreas and kidney of diabetic rats exhibited considerable changes, like cellular necrosis. These changes in diabetic treatment groups were at lowest amounts. The decrease levels of creatinine, liver enzymes, and other factors were supporting these changes. Conclusions: This study demonstrates that the CS fruit extract could be aid prevention of damage to the tissues due to the decreased levels of harmful oxidants in the body in diabetes. Moreover, according to our previous results altogether we showed beneficial impact of the plant on the treatment of diabetes.
Highlights
Diabetes is one of the most frequent metabolic diseases with absolute or relative insulin deficiency and hyperglycemia-induced, associated with the long-term ocular, renal, cardiovascular, and nervous system complications [1,2]
This study demonstrates that the Capparis Spinosa (CS) fruit extract could be aid prevention of damage to the tissues due to the decreased levels of harmful oxidants in the body in diabetes
These changes were not seen in normal group and diabetic treatment group VI (Figure 1)
Summary
Diabetes is one of the most frequent metabolic diseases with absolute or relative insulin deficiency and hyperglycemia-induced, associated with the long-term ocular, renal, cardiovascular, and nervous system complications [1,2]. A balance between production and elimination of free radicals is observed in normal situations Imbalance in this process lead to develop severe or prolonged oxidative stress which causes serious damage to the cells [7]. Some parts of Iran are of appropriate regions for growing CS [13] This plant is used in traditional medicine as a diuretic, treatment of gout arthritis, rheumatoid, paralysis and neurological conditions as well as liver disorders [14]. Several bio-materials including alkaloids, lipids, polyphenols and flavonoids isolated from different parts of CS [15] It is known as the herb-rich source of flavonoids such as kaempferol, Received June 18 2014; Accepted October 10, 2014; Published October 13, 2014
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
