Outcome Following Highly Conformal SIB-IMRT for T1/2 Glottic Cancer – Single Institution Update

Abstract

to update our single institution prospective Outcome data of partial laryngeal- and/or carotid artery- sparing SIB-IMRT in T1/2 glottic Cancer. Between 12/2004-10/2015, 67 consecutive patients with cT1/2 (35/32) cN0 glottic carcinoma were definitively irradiated using conformal SIB-IMRT techniques at the department of Radiation Oncology, University Hospital Zurich. In 59/67 patients the anterior commissure was involved. Treatment schedules included 5x 2.0Gy/w to 70Gy or 6x 2.0Gy/w to 68 or 5x2.25Gy/w to 63Gy for PTV1. Mean follow up was 48 months (1.4-113), mean/median age of patients was 66.7/67 years (38-87). The mean dose to the ipsilateral contoured segment of the carotid artery could be kept <30Gy. Partial larynx sparing was not indicated in 15/67 patients due to the tumor extension. We observed 4/67 local failures; three of the affected patients underwent successful salvage laryngectomy, one patient underwent successful laser therapy. The 3-year local and locoregional disease free survival rates were 93.8 and 94%, the overall survival rate was 90%, respectively. One cT2 patient with no signs of disease unfortunately died 10 months post IMRT completion due to unexpected massive laryngeal edema with consecutive unsuccessful intubation. Another cT2 patient developed distant disease. Presented results confirm our previous findings of small volume conformal SIB-IMRT being safe and effective in T1/2 glottic cancer. Local recurrence localization and comparison with the literature will be presented.