Outcome comparisons of high-grade glioma resection with or without fluorescein sodium-guidance

Abstract

To compare surgical outcomes and adverse events between patients received microsurgical resection of high-grade gliomas with or without fluorescein sodium-guidance. A retrospective study was conducted in our hospital between June 2016 and January 2017. Patients were divided into 2 groups: Fluorescein Group (42 patients) and Nonfluorescein Group (40 patients). Intraoperative (hemorrhage value and operation time) and postoperative (consistency between fluorescence-stained tissue and histopathological results, rate of resection) measurements were documented. Postoperative adverse events were recorded. Patients were followed up for 6 months to evaluate postsurgery glioma recurrence. Intraoperatively, hemorrhage value, and operation time were significantly less in Fluorescencein than in Nonfluorescencein group. The rate of glioma complete resection was significantly higher in Fluorescencein than in Nonfluorescencein group (85.7%vs 62.5%, P = 0.02). The rate of glioma recurrence was significantly lower in Fluorescencein than in Nonfluorescencein group (11.9%vs 25.0%, P = 0.01), and no significant differences on adverse events were observed. Intraoperative fluorescein sodium-guidance could facilitate the complete resection and significantly decrease the postoperative recurrence in patients with high-grade gliomas.