Outcome and risk of ocular complications of managing children with chronic anterior uveitis with topical rimexolone 1.

Abstract

To investigate the efficacy and safety of 1% rimexolone ophthalmic suspension in children with chronic anterior uveitis under real-life conditions in a tertiary center. This is a retrospective longitudinal study. Medical records were analyzed at baseline, 1, 3, 6 and 12months before and after switching to rimexolone for best-corrected visual acuity (BCVA), oral steroid use, number of flares, IOP and anti-glaucoma management. Twenty-four patients (41 eyes) diagnosed with either anterior uveitis (n = 25, 60.0%) or panuveitis (n = 16, 40%) were enrolled. The mean age was 10.5years (4-16years). The number of patients requiring oral prednisolone reduced from 8 patients (32.0%) at baseline to 3 patients (20.0%) at 12months (P < 0.001). Following baseline, the median number of uveitis flares reduced from 2.0 (inter-quartile range (IQR) 1.0-2.75) to 1.0 (IQR 0.0-1.0) compared to the 12months before baseline (P < 0.001). The mean IOP reduced from baseline (22.0 ± 7.3mmHg) to 1month (18.8 ± 8.7mmHg, P = 0.01) and remained stable up to 12months (15.9 ± 5.0mmHg, P < 0.001). Average BCVA, dose of oral prednisolone and anti-glaucoma treatments did not change compared to the baseline. The development for IOP ≥ 30mmHg was associated with a known corticosteroid response [odds ratio (OR) 6.8, P = 0.003] and a dose > 7.5mg/day oral prednisolone (OR 4.4, P = 0.033). Rimexolone 1% ophthalmic suspension is an effective and safe topical steroid for pediatric anterior uveitis.