Outcome analysis of infertile patients with polycystic ovarian syndrome after in vitro fertilization and embryo transfer

Abstract

Objective To investigate the outcome of infertile patients with polycystic ovarian syndrome (PCOS) after in vitro fertilization and embryo transfer (IVF-ET). Methods Clinical data of PCOS group with 74 IVF-ET cycles and control group (tubal infertility) with 657 IVF-ET cycles from 2003 to 2006 in our center were analyzed retrospectively. Gonadotropin (Gn) dosage and duration of ovarian stimulation, numbers of retrieved oocytes, normal fertilization rate, cleavage rate, numbers of embryo transfer, available embryo rate, and serum sex hormone before and during ovarian stimulation, and pregnancy outcome were compared between two groups. Results PCOS group had lower basal follicle stimulating hormone (FSH) [(5.74±1.74) U/L vs (6.63±1.95) U/L], higher basal luteine hormone (LH) [(7.68±4.84) U/L vs (4.76±2.61) U/L], LH/FSH (1.38±0.88 vs 0.75±0.42) and total testerone (T) [(2.07±1.0) nmol/L vs (1.54±0.60)nmol/L] as compared with control group (P 0.05). There were no significant differences in total Gn dosage, duration of giving Gn, numbers of oocytes, normal fertilization rate, cleavage rate, numbers of ET and available embryo rate (P>0.05). No significant differences were found in chemical and clinical pregnancy rate, implantation rate, multiple pregnancy rate, ectopic pregnancy rate and preterm rate (P>0.05). But compared with control group, PCOS group had significantly higher pregnancy loss rate (50% vs 20%), significantly lower delivery rate (46% vs 80%) and take-baby-home rate (16% vs 30%) per ET cycle (P <0.05). Conclusion PCOS patients have higher pregnancy loss rate after IVF-ET, and more effective intervention should be studied to improve pregnancy outcome. Key words: Polycystic ovarian syndrome; Pregnancy loss; In vitro fertilization; Embryo transfer; Infertility; Sex hormone