Abstract
ABSTRACT: Forty 1-2-y-old water buffaloes were simultaneously treated with trichlorfon and chlorpyrifos products in the recommended dose for cattle. After a week, 19 animals started presenting clinical signs characterized by apathy, diarrhea, aggressiveness, dehydration, and motor incoordination, followed by flaccid paralysis and permanent lateral recumbency. All affected buffaloes died after a clinical course of 1-4 days. Reduction of serum cholinesterase activity in three cases was indicative of significant exposure to organophosphorus compounds (OPs). Pathological examination of three buffaloes revealed no gross and histological lesions. By thin layer chromatography, chlorpyrifos residues and trace of trichlorfon residues were detected in fresh tissue samples. The epidemiological, clinical, pathological, and toxicological findings were highly compatible with OPs-induced delayed neurotoxicity, a neurological manifestation rarely described in domestic animals.
Highlights
RESUMO: Quarenta búfalos foram simultaneamente tratados com clorpirifós e triclorfom na dose recomendada para bovinos
Similar accidental acute poisoning or chronic toxicity by Organophosphorus compounds (OPs) may affect all farm animals (CONSTABLE et al, 2017); natural poisoning by OPs in buffaloes has been rarely described in the literature (GRECCO et al, 2009)
We reported an outbreak of OPs-induced delayed neurotoxicity (OPIDN) in a herd of domestic water buffaloes (Bubalus bubalis)
Summary
RESUMO: Quarenta búfalos foram simultaneamente tratados com clorpirifós e triclorfom na dose recomendada para bovinos. Similar accidental acute poisoning or chronic toxicity by OPs may affect all farm animals (CONSTABLE et al, 2017); natural poisoning by OPs in buffaloes has been rarely described in the literature (GRECCO et al, 2009). The main risk factor associated with the only natural poisoning by OPs in buffaloes described in the literature was the use of chlorpyrifos in the recommended dose for cattle (12 mg/Kg) (GRECCO et al, 2009). In this outbreak, both chlorpyrifos and trichlorfon products were applied based on the recommendations for cattle (resulting in a total dose of OPs of 14.5–19.5 mg/Kg). The exact mechanism of NTE inhibition leading to OPIDN is
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