Abstract
204 children were affected in an epidemic of percutaneous hexachlorophene poisoning in France, and 36 of them died. The syndrome consisted of ulcerative skin lesions and an encephalopathy. The source of the toxic agent was a talc "baby powder" which, because of a manufacturing error, contained 6·3% hexachlorophene. The cause of the epidemic was confirmed by chemical analysis of the talc, high hexachlorophene levels in affected children, characteristic histological findings, and toxicity tests of the talc in animals.
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