Abstract
We have used Mitomycin C while treating patients with difficult laryngeal stenosis, stenosis of the subglottic area, and also for patients suffering from choanal atresia. The stenosis was originally caused by posttraumatic, post-intubation, and congenital causes. Mitomycin C was used locally after laryngotracheoscopy and dilatation, or after rhinoscopy and dilatation of the choanal atresia. Mitomycin C was applied intraoperatively on saturated pledgets at a dose of 0.4 mg/ml for 4–7 min to the area where the scar had been lysed. The therapy was successful in 70% of cases. Mitomycin C is an antimetabolite known to inhibit fibroblast proliferation in vitro. The use of Mitomycin C for treating scar tissue in otolaryngology cases seems to be more than useful.
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