Our experiences with pancreatoduodenectomy: risk factors and outcomes analysis

Abstract

Pancreatoduodenectomy (PD) is the main surgical option for pancreatic neoplasms, duodenal neoplasms and other lesions located in the pancreatic head and periampullary region. Despite the prompt progress in surgical technologies and the persistent innovation of postoperative treatments over the last decades, post-pancreaticoduodenectomy complications (PPCs) remains high, which may lead to several potential poor outcomes, including prolonged hospital stays, increased medical costs and mortality. The purposes of this study were to analyze all type of PPCs and to identify associated factors related. Cross-sectional design was used. Patients, who underwent PD in Fatmawati General Hospital Jakarta between January 2017 and December 2018 were retrospectively analyzed. We classify PPCs for 45 patients who had undergone PD, ten variables were considered significant predictors of serious complications. The predictors included age, sex, obesity, smoking status, the presence of a comorbidity, nutritional status, combined vascular resection, intraoperative blood transfusion, serum albumin and bilirubin laboratory. Clinically, the most relevant postoperative complication of PD is a pancreatic fistula (PF), which is often associated with the development of life-threatening intra-abdominal complications. Pancreaticoduodenectomy remains the only curative option for patients with a malignant neoplasm. Good preoperative assessment and preparation support reduced the morbidity and mortality rate associated with PD