Abstract
We determined PRA and Angio II (Kit of CEA-CEN-SORIN) in some hundred cases in two different technical conditions: (A) pH = 7; DFP as inhibitor (B) pH = 5.5 and BAL-IC. Results: in a group of normal children at normal and constant diet PRA was: 0.64 ± 0.46 ng/ml/h. In 30 infants (8 h. – 11 m.) the mean value was: 0.75±0.27. The correlation between PRA and Angio II values (107 children) was highly significant; in spite of this we no longer measure Angio II with the kit because of the cross reactivity with the hepta and hexapeptide. (B) at pH = 5.5 the PRA values were higher. In 10 normal children (5–12 years) at a constant sodium intake of 50 mEq/m2/day, the mean PRA value in supine position after overnight fasting and rest was: 1.11 ± 0.36; after 30–40 min. exercise was: 2.88 ± 0.34. The previous experience (A) of independence of PRA from hypertension, azotemia etc. was confirmed. The sodium intake and position playan overwhelming role in determining the height of PRA values. Finally, the results obtained in some selected conditions or pathological cases are reported.
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