Abstract
To understand the mechanism of reduced number of sodium pump units (ouabain-binding sites, OBS) of erythrocytes in hyperthyroidism, OBS of reticulocytes from guinea pigs injected with triiodothyronine (T 3) were measured. Reticulocytosis was induced in 16 guinea pigs by withdrawing 6 to 10 mL of blood for 5 days followed by 2 days rest. T 3 ( 50 μ g 100 g body weight) was injected into seven animals on days 4 and 6, and the remainder were injected with solvent for T 3. Reticulocyte-rich blood was withdrawn on day 8. Oxygen consumption determined 24 hours after the first injection of T 3 was 30% higher in the T 3-treated animals ( P < .001). OBS of reticulocytes from control animals were sixfold higher than that of mature erythrocytes. Reticulocytes from T 3-treated guinea pigs had significantly lower OBS ( P < .01) compared with controls. We conclude that the loss of OBS induced by thyroid hormones probably occurs during the formation of reticulocytes.
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