Abstract
To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects. Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created on dorsal part of shaved rats using a metal rod. In group I the burn wound was left without any treatment. Group was treated with topical silver sulfadiazine pomade. In group III, ointment containing the OP extract was administered. Skin biopsies were harvested from burn area on the 3rd, 5th, 14th and 21st days after burn and examined histologically. Re-epithelialization in the control group and in group II was lower than in group III. Re-epithelialization in groups II and III was significantly different from that in the control group. On the 5th day of the experiment, we assessed lower inflammation in the burn area compared to control group. This means that the inflammation was suppressed by methanolic extract of OP. From day 5 to 14; the fibroblast proliferation peaked and was associated with increased collagen accumulation. It was obvious that angiogenesis improved more in the groups II and III, which facilitated re-epithelialisation. Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site.
Highlights
Burn wound treatment is one of the challenges in the medical science
Excessive inflammation leading to increased vascular permeability, local tissue edema and neutrophil activation that cause local tissue damage[1]
The inflammation in groups I and II on day 3 was severe in the burn area (Figure 1)
Summary
Burn wound treatment is one of the challenges in the medical science. Excessive inflammation leading to increased vascular permeability, local tissue edema and neutrophil activation that cause local tissue damage[1]. New wound healing compounds are welcomed for accelerating regenerating process for its anti-inflammatory and antimicrobial effects. The interest in natural antioxidants has been increased considerably. As resources of natural antioxidants much attention has been paid to plants[2,3]. The antioxidant activity of several Iranian plants has been reported[4]
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