Other Noteworthy Papers This Week

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J. L. Avalos, I. Celic, S. Muhammad, M. S. Cosgrove, J. D. Boeke, C. Wolberger, Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol. Cell 10 , 523-535 (2002). [Abstract] [Full Text] A. W. Bird, D. Y. Yu, M. G. Pray-Grant, Q. Qiu, K. E. Harmon, P. C. Megee, P. A. Grant, M. M. Smith, M. F. Christman, Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature 419 , 411-415 (2002). [Abstract] [Full Text] K. J. Bitterman, R. M. Anderson, H. Y. Cohen, M. Latorre-Esteves, D. A. Sinclair, Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1. J. Biol. Chem., 23 September 2002 [e-pub ahead of print]. [Abstract] [Full Text] W. Duan, X. Zhu, B. Ladenheim, Q.-S. Yu, Z. Guo, J. Oyler, R. G. Cutler, J. L. Cadet, N. H. Greig, M. P. Mattson, p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann. Neurol. , 24 September 2002 [e-pub ahead of print]. [Abstract] [Full Text] T. Jonassen, B. N. Marbois, K. F. Faull, C. F. Clarke, P. L. Larsen, Development and fertility in C. elegans clk-1 mutants depends upon transport of dietary coenzyme Q8 to mitochondria. J. Biol. Chem., 24 September 2002 [e-pub ahead of print]. [Abstract] [Full Text] J. Lund, P. Tedesco, K. Duke, J. Wang, S. K. Kim, T. E. Johnson, Transcriptional profile of aging in C. elegans. Curr. Biol. 12 , 1566-1573 (2002). Suggested by Nick Bishop. [Abstract] [Full Text] M. M. Ramsey, R. L. Ingram, A. B. Cashion, A. H. Ng, J. M. Cline, A. F. Parlow, W. E. Sonntag, Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology 143 , 4139-4142 (2002). Suggested by James M. Harper. [Abstract] [Full Text]