Abstract

Crystal-associated arthritis usually connotes either monosodium urate mono-hydrate (MSU) or calcium pyrophosphate dihydrate (CPPD) crystals. These twocrystals are easily detected and identified by polarized light microscopy. Lesscommon crystals, such as cholesterol and oxalate, may also be visualized bypolarized light microscopy. Basic calcium phosphate (BCP) crystals, on the otherhand, found in up to 60% of cases of knee osteoarthritis, usually can not beidentified by this technique (1). The failure of polarized light microscopy todetect BCP crystals relates to the very small size of the crystals and the randomorientation of crystals within a crystal mass. In rare cases, BCP crystals may bevisualized with the light microscope as refractile “shiny coins” which representlaminations of crystals in a globular mass (2). Thus, other means have beennecessary to identify BCP crystals.

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