Abstract
Quercetin, a valuable natural flavonoid, has demonstrated a wide range of biological activities by modulating various targets and signaling pathways. However, Quercetin's low solubility and poor bioavailability have limited its applicability; as a result, researchers have attempted to design and synthesize numerous novel Quercetin derivatives using various methodologies to modify Quercetin's constraints and improve its biological activities. The biological activities, structure-activity relationship (SAR), and action mechanism of a range of O-alkylated or arylalkylated, O-acylated, and O-heteroaromatic derivatives of Quercetin were reviewed in this research. These derivatives have shown anti-cancer, anti-oxidant, anti-bacterial, anti-inflammatory, anti-alzheimer, anti-fungal, anti-viral, anti-thalassemia, or iron chelation, anti-obesity, anti-diabetic, and anti-hypertension. In addition, we compiled a list of past and current research projects aimed to develop new potent lead compounds.
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