Abstract
10039 Background: Treatment of pelvic and sacrum osteosarcoma (OS) poses challenges for local control and outcome. Data are scarce since these patients (pts) are often not eligible for chemotherapy protocols. Methods: All pts with high grade pelvic or sacral OS admitted to the Rizzoli Institute between 1998 and 2010 were included in this retrospective study. Results: 73 pts (40 male) were identified; median age was 32 years (8-72); 60 (82%) had pelvic and 13 (18%) sacral lesions. Fifty-five (75%) pts presented with localized disease. Forty-eight (66%) underwent surgery (and hindquarter amputation in 37% of cases, with adequate surgical margins in 78%). A surgical complete remission (SCR) was achieved in 56% of pts. Chemotherapy: 3 Drugs [cisplatin, adriamycin and standard dose ifosfamide (IFO)] were administered to 16 pts; 4 Drugs (cisplatin, adriamycin, IFO and methothrexate) to 19 pts; 4 Drugs with high dose ifosfamide (HDIFO: 15 gr/m2) in 21. Four pts did not receive chemotherapy; 13 pts received other...
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