Abstract
Osteoprotegerin (OPG) is involved in the development of atherosclerosis and cardio-cerebrovascular disease. The goal of this meta-analysis was to evaluate the association of OPG single nucleotide polymorphisms (SNPs) with coronary artery disease (CAD) and ischemic stroke. A total of 15 eligible studies were extracted from electronic databases. Odds ratios (ORs) were presented, with 95% confidence intervals (CIs), to assess the associations. Meta-analysis was conducted using MetaGenyo, STATA, and Comprehensive Meta-Analysis. Meta-analysis of our data showed that the OPG SNP T950C was significantly associated with increased CAD risk among Asians via recessive (OR 1.55, 95% CI 1.18–2.04, P=0.002), CC vs TT (OR 1.57, 95% CI 1.16–2.11, P=0.003) and allelic (OR 1.21, 95% CI 1.05–1.38, P=0.007) models. No strong associations were observed for the OPG SNP G1181C, T245G and G209A with CAD risk. When evaluating the OPG SNP T245G and T950C associations with ischemic stroke, we found the OPG SNP T245G to be significantly associated with increased risk of ischemic stroke among Chinese via recessive (OR 1.53, 95% CI 1.02–2.29, P=0.039) and CC vs AA (OR 1.61, 95% CI 1.07–2.42, P=0.021) models. Our results suggested that the OPG SNP T950C was associated with increased risk of CAD among Asians, and the OPG SNP T245G was associated with enhanced ischemic stroke risk among Chinese.
Highlights
Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily, termed as TNF receptor superfamily member 11B (TNFRSF11B) [1]
In the overall meta-analysis and stratification analysis based on ethnicity, we found no association between these single nucleotide polymorphism (SNP) and coronary artery disease (CAD) risk (Table 3)
CAD is the major cause of fatality and disability for both men and women in the world
Summary
Osteoprotegerin (OPG) is a member of the tumor necrosis factor (TNF) receptor superfamily, termed as TNF receptor superfamily member 11B (TNFRSF11B) [1]. Increased levels of OPG were strongly predictive of long-term mortality of CAD patients [13,14]. Based on these observations, OPG was thought to be a potential new biomarker for cardio-cerebrovascular disease. There are several common single nucleotide polymorphisms (SNPs) identified in the OPG gene, including T950C (T→C, promoter), T245G (T→G, promoter), G209A (G→A, promoter), and G1181C (G→C, exon 1). These SNPs affect circulating OPG levels or protein function [15].
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